Sophia Thomalla is the daughter of Simone Thomalla and André Vetters, both also actors. She grew up on to her seventh year in Berlin and then moved with her mother in Cologne. After completion of the fourth school year, she and her mother moved back to Berlin, then after a year to Gelsenkirchen, where they lived after the separation from her mother Rudi Assauer. In the fall of 2009 she moved to Berlin for work again.
Thomalla studied from 2007 to 2009 in Bochum at the Constantin-acting school.
Through the friendly television director Sigi Rothemund in 2006 she received her first television role in the thriller series ARD Commissario Laurenti, in which she collected as a movie daughter of Barbara Rudnik and Henry Hübchen first acting experience. Part of the beautiful Livia Laurenti, who dreams of attending a pageant, Thomalla embodied in the following four parts.